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Kraig, Richard

One or more keywords matched the following properties of Kraig, Richard

Property	Value
keywords	migraine, enrichment, green exercise, exosomes, IGF-1, multiple sclerosis, trauma
overview	Dr. Richard Kraig is an expert in migraine patient care, migraine research and cerebrovascular disease research. His clinical interests focus on the diagnosis and treatment of migraine headaches. He oversees the Cerebrovascular Disease and Aging Laboratories, which focus on migraine, stroke, epilepsy and cognitive decline from aging. An active researcher, Dr. Kraig leads investigations to determine how physical, mental and social activities can lessen the impact of neurological disease. Examination of such mechanisms by which the brain naturally protects itself may lead to more selective cellular and molecular targets, as well as new therapeutic strategies against brain disease. Dr. Kraig's research helps him to develop individualized treatment plans for patients in the Migraine Headache Clinic. He is also involved in teaching medical students, graduate students and residents.

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Value

keywords

migraine, enrichment, green exercise, exosomes, IGF-1, multiple sclerosis, trauma

overview

Dr. Richard Kraig is an expert in migraine patient care, migraine research and cerebrovascular disease research. His clinical interests focus on the diagnosis and treatment of migraine headaches. He oversees the Cerebrovascular Disease and Aging Laboratories, which focus on migraine, stroke, epilepsy and cognitive decline from aging. An active researcher, Dr. Kraig leads investigations to determine how physical, mental and social activities can lessen the impact of neurological disease. Examination of such mechanisms by which the brain naturally protects itself may lead to more selective cellular and molecular targets, as well as new therapeutic strategies against brain disease. Dr. Kraig's research helps him to develop individualized treatment plans for patients in the Migraine Headache Clinic. He is also involved in teaching medical students, graduate students and residents.

One or more keywords matched the following items that are connected to Kraig, Richard

Item Type	Name
Concept	Actins
Concept	Action Potentials
Concept	Adrenergic alpha-Agonists
Concept	Amygdala
Concept	Acetazolamide
Concept	Cyclic AMP
Concept	Acid-Base Equilibrium
Concept	Acidosis
Concept	Adenosine Triphosphate
Concept	Administration, Intranasal
Concept	Antigens, Differentiation
Concept	Cats
Concept	Cell Membrane Permeability
Concept	Cerebral Cortex
Concept	Anesthetics, Local
Concept	Chlorides
Concept	Analysis of Variance
Concept	Antibody Specificity
Concept	B-Lymphocytes
Concept	Cell Count
Concept	Cell Differentiation
Concept	Cell Movement
Concept	Cerebral Infarction
Concept	Cerebrovascular Circulation
Concept	Dimethadione
Concept	Brain Injuries
Concept	Autoradiography
Concept	Chemistry Techniques, Analytical
Concept	Carbonic Acid
Concept	Biological Transport
Concept	Biophysics
Concept	Barium
Concept	Bicarbonates
Concept	Brain
Concept	Brain Chemistry
Concept	Capillary Permeability
Concept	Cell Division
Concept	Carbonates
Concept	Central Nervous System
Concept	Cerebellum
Concept	Capillaries
Concept	Blood-Brain Barrier
Concept	Cold Temperature
Concept	Caffeine
Concept	Cholesterol
Concept	Electric Fish
Concept	Electrophysiology
Concept	Cholelithiasis
Concept	Depression
Concept	Fishes
Concept	Indoles
Concept	Indomethacin
Concept	Motor Cortex
Concept	Frontal Lobe
Concept	Hippocampus
Concept	Hydrogen Peroxide
Concept	Insulin-Like Growth Factor I
Concept	Enzyme-Linked Immunosorbent Assay
Concept	Endotoxins
Concept	Housing, Animal
Concept	Flow Cytometry
Concept	Interleukin-1
Concept	Leukocytes
Concept	Phenylephrine
Concept	Mammals
Concept	Potassium Chloride
Concept	Protein Denaturation
Concept	Immunohistochemistry
Concept	Necrosis
Concept	Mice, Inbred C57BL
Concept	Migraine Disorders
Concept	Rats, Inbred SHR
Concept	Synaptic Transmission
Concept	Masoprocol
Concept	Lipopolysaccharides
Concept	Trigeminal Ganglion
Concept	Meninges
Concept	Parietal Lobe
Concept	Phosphorylation
Concept	Nitroprusside
Concept	Oxygen
Concept	Trigeminal Nuclei
Concept	Immunoglobulin G
Concept	Rats, Inbred F344
Concept	Regional Blood Flow
Concept	Rats, Inbred WKY
Concept	Tetrodotoxin
Concept	Humans
Concept	Fura-2
Concept	Styrenes
Concept	Synapses
Concept	Intracellular Membranes
Concept	United States
Concept	Tumor Necrosis Factor-alpha
Concept	Trigeminal Caudal Nucleus
Concept	Calcium Channels
Concept	Dinoprostone
Concept	Up-Regulation
Concept	Ion Channel Gating
Concept	Mitochondria
Concept	Multiple Sclerosis
Concept	Second Messenger Systems
Concept	Interleukin-10
Concept	Proto-Oncogene Proteins c-fos
Concept	Cytochalasin D
Concept	Eicosanoids
Concept	Rats, Sprague-Dawley
Concept	Rats, Wistar
Concept	Myelin Sheath
Concept	Cyclooxygenase Inhibitors
Concept	Apoptosis
Concept	Cell Proliferation
Concept	Entorhinal Cortex
Concept	Sodium Acetate
Concept	Cyclooxygenase 2 Inhibitors
Concept	Calcium Channels, P-Type
Concept	Calcium Signaling
Concept	Excitatory Amino Acid Agonists
Concept	rab GTP-Binding Proteins
Concept	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
Concept	Serum
Concept	Green Fluorescent Proteins
Concept	Chloride Channels
Concept	Ectodysplasins
Concept	Interleukin-1beta
Concept	Migraine with Aura
Concept	Portacaval Shunt, Surgical
Concept	Mice
Concept	Endosomes
Concept	Rats, Inbred Strains
Concept	Sodium Chloride
Concept	Tea
Concept	Rats
Concept	Nitric Oxide Synthase Type II
Concept	Temperature
Concept	Blotting, Western
Concept	Cell Death
Concept	Blotting, Northern
Concept	Interleukin-11
Concept	N-Methylaspartate
Concept	Dentate Gyrus
Concept	Calcium Channels, Q-Type
Concept	Sumatriptan
Concept	CA1 Region, Hippocampal
Concept	Neocortex
Concept	Exosomes
Concept	Antibodies
Concept	Axons
Concept	Benzylidene Compounds
Concept	Brain Neoplasms
Concept	Calcium
Concept	Calcium Channel Blockers
Concept	Cerebellar Nuclei
Concept	Cerebral Arteries
Concept	Brain Ischemia
Concept	Hypothalamus
Concept	Kinetics
Concept	Lysine
Concept	Membrane Potentials
Concept	Somatosensory Cortex
Concept	T-Lymphocytes
Concept	Signal Transduction
Concept	Receptors, Calcitonin Gene-Related Peptide
Concept	Gelsolin
Concept	Potassium Channels, Voltage-Gated
Concept	MicroRNAs
Concept	Biophysical Phenomena
Concept	CA3 Region, Hippocampal
Academic Article	Long-term elevation of cyclooxygenase-2, but not lipoxygenase, in regions synaptically distant from spreading depression.
Academic Article	Neocortical spreading depression provokes the expression of c-fos protein-like immunoreactivity within trigeminal nucleus caudalis via trigeminovascular mechanisms.
Academic Article	Whole-cell chloride currents in rat astrocytes accompany changes in cell morphology.
Academic Article	Eicosanoids and nitric oxide influence induction of reactive gliosis from spreading depression in microglia but not astrocytes.
Academic Article	Cytoskeletal actin gates a Cl- channel in neocortical astrocytes.
Academic Article	Comment on Ingvardsen et al., PAIN, 72 (1997) 407-415.
Academic Article	Reactive astrocytosis from excitotoxic injury in hippocampal organ culture parallels that seen in vivo.
Academic Article	Astroglial acid-base dynamics in hyperglycemic and normoglycemic global ischemia.
Academic Article	Prostaglandin E receptor subtypes in cultured rat microglia and their role in reducing lipopolysaccharide-induced interleukin-1beta production.
Academic Article	Neuronal nitric oxide synthase expression is induced in neocortical astrocytes after spreading depression.
Academic Article	Calcium waves precede electrophysiological changes of spreading depression in hippocampal organ cultures.
Academic Article	Astrocytic clasmatodendrosis in hippocampal organ culture.
Academic Article	Prostaglandin E2 and 4-aminopyridine prevent the lipopolysaccharide-induced outwardly rectifying potassium current and interleukin-1beta production in cultured rat microglia.
Academic Article	Carbonic acid buffer species measured in real time with an intracellular microelectrode array.
Academic Article	Hippocampal spreading depression bilaterally activates the caudal trigeminal nucleus in rodents.
Academic Article	Intracellular pH rises and astrocytes swell after portacaval anastomosis in rats.
Academic Article	Spreading depression increases immunohistochemical staining of glial fibrillary acidic protein.
Academic Article	Homeostatic plasticity in hippocampal slice cultures involves changes in voltage-gated Na+ channel expression.
Academic Article	P/Q Ca2+ channel blockade stops spreading depression and related pyramidal neuronal Ca2+ rise in hippocampal organ culture.
Academic Article	Optimization of multiplexed bead-based cytokine immunoassays for rat serum and brain tissue.
Academic Article	Optical current source density analysis in hippocampal organotypic culture shows that spreading depression occurs with uniquely reversing currents.
Academic Article	Ionic concomitants of astroglial transformation to reactive species.
Academic Article	Astrocytic acidosis in hyperglycemic and complete ischemia.
Academic Article	Multiplexed cytokine protein expression profiles from spreading depression in hippocampal organotypic cultures.
Academic Article	Cold pre-conditioning neuroprotection depends on TNF-a and is enhanced by blockade of interleukin-11.
Academic Article	Modeling neural immune signaling of episodic and chronic migraine using spreading depression in vitro.
Academic Article	Spreading depression sends microglia on Lévy flights.
Academic Article	Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma.
Academic Article	Differential effects of low-dose endotoxin on the cerebral circulation during pregnancy.
Academic Article	Compartmentation of acid-base balance in brain during complete ischemia.
Academic Article	Sodium liquid ion exchanger microelectrode used to measure large extracellular sodium transients.
Academic Article	Carbonic acid buffer changes during complete brain ischemia.
Academic Article	TNF-a and Microglial Hormetic Involvement in Neurological Health & Migraine.
Academic Article	Astroglial H+ and Ca2+ changes--signals for cell activation?
Academic Article	Insulin-like growth factor-1 lowers spreading depression susceptibility and reduces oxidative stress.
Academic Article	Hydrogen ion buffering during complete brain ischemia.
Academic Article	Acid-induced injury in elasmobranch brain.
Academic Article	Astrocyte precursor response to embryonic brain injury.
Academic Article	Bicarbonate and ammonia changes in brain during spreading depression.
Academic Article	Acid-induced changes of brain protein buffering.
Academic Article	Hydrogen ions kill brain at concentrations reached in ischemia.
Academic Article	The effects of extracellular acidosis on neurons and glia in vitro.
Academic Article	Isotopic dilution analysis. Cholesterol in gallstones and caffein in tea, cola, and NoDoz.
Academic Article	Characterization of inducible cyclooxygenase in rat brain.
Academic Article	Potassium, calcium, chloride and sodium changes in extracellular space during spreading depression in cerebellum [proceedings].
Academic Article	Heterogeneous distribution of hydrogen and bicarbonate ions during complete brain ischemia.
Academic Article	Chloride and potassium changes measured during spreading depression in catfish cerebellum.
Academic Article	Monomeric IgG is neuroprotective via enhancing microglial recycling endocytosis and TNF-alpha.
Academic Article	Alkaline and acid transients in cerebellar microenvironment.
Academic Article	Light and electron microscopic evaluation of hydrogen ion-induced brain necrosis.
Academic Article	Intracellular pH of astrocytes increases rapidly with cortical stimulation.
Academic Article	In vivo measurement of regional brain and tumor pH using [14C]dimethyloxazolidinedione and quantitative autoradiography. II: Characterization of the extracellular fluid compartment using pH-sensitive microelectrodes and [14C]sucrose.
Academic Article	Extracellular ionic variations during spreading depression.
Academic Article	Focal elevations in neocortical interstitial K+ produced by stimulation of the fastigial nucleus in rat.
Academic Article	Dynamics of interstitial and intracellular pH in evolving brain infarct.
Academic Article	Intracellular pH transients of mammalian astrocytes.
Academic Article	Determination of extracellular bicarbonate and carbon dioxide concentrations in brain slices using carbonate and pH-selective microelectrodes.
Academic Article	Insulin-like growth factor-1 abrogates microglial oxidative stress and TNF-a responses to spreading depression.
Academic Article	IFN?-stimulated dendritic cell exosomes as a potential therapeutic for remyelination.
Academic Article	Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination.
Academic Article	What are exosomes and how can they be used in multiple sclerosis therapy?
Academic Article	Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment.
Academic Article	Phasic Treatment with Interferon Gamma Stimulates Release of Exosomes that Protect Against Spreading Depression.
Academic Article	Environmental Enrichment Stimulates Immune Cell Secretion of Exosomes that Promote CNS Myelination and May Regulate Inflammation.
Academic Article	Seizures in Women with Preeclampsia: Mechanisms and Management.
Academic Article	NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface.
Academic Article	Intranasally administered IGF-1 inhibits spreading depression in vivo.
Academic Article	IFN?-Stimulated Dendritic Cell Exosomes for Treatment of Migraine Modeled Using Spreading Depression.
Academic Article	Insulin-like growth factor-1 inhibits spreading depression-induced trigeminal calcitonin gene related peptide, oxidative stress & neuronal activation in rat.
Academic Article	Insulin-like growth factor-1 inhibits nitroglycerin-induced trigeminal activation of oxidative stress, calcitonin gene-related peptide and c-Fos expression.
Academic Article	Environmental Enrichment and Its Benefits for Migraine: Dendritic Cell Extracellular Vesicles as an Effective Mimetic.
Academic Article	IFN?-stimulated dendritic cell extracellular vesicles can be nasally administered to the brain and enter oligodendrocytes.
Concept	Cervical Cord
Grant	Exosome RNA-Therapeutics to Promote CNS Myelination
Grant	MULTIPLEXED &CELL-SPECIFIC ANALYSES OF BRAIN FUNCTION
Grant	Environment Enrichment, Neuroprotection and Spreading Depression
Grant	Exosome RNA-Therapeutics to Promote CNS Myelination
Grant	Development of Nasal IGF-1 as a Migraine Therapeutic

Search Criteria

migraine
enrichment
green
exercise
exosomes
IGF
1
multiple sclerosis
trauma